The virus has been reported to lead to a syndrome similar to Kawasaki disease in children infected.
At least 73 children in New York have been diagnoses with symptoms of Kawasaki and something similar to toxic shock syndrome.
Kawasaki diseases is a rare inflammatory condition in children, usually linked to genetics.
Most of the children infected with these symptoms are reportedly toddlers or of elementary age.
While new information is being learned about the virus, there is currently no proof that COVID-19 can cause the two syndromes.
Governor Andrew Cuomo announced the grim developments on Saturday at a New York City hospital.
Cuomo announced two more deaths a day after discussing the death of a five-year-old boy Thursday at a New York City hospital.
He did not give information about where the two other children died, or provide their ages.
Cuomo also said that the children had tested positive for COVID-19 or the antibodies but did not show the common symptoms of the virus when they were hospitalised.
He said at his daily briefing: “This is the last thing that we need at this time, with all that is going on, with all the anxiety we have, now for parents to have to worry about whether or not their youngster was infected.”
New York City reported on Monday that 15 patients aged between two and 15 had been hospitalised over the past three weeks with the COVID-related syndrome.
The death of the five-year old boy marks the first fatality from the new illness in the US.
Seattle has reported a case along with a team at California’s Stanford children’s hospital.
Other countries have also seen the grim new development in children.
A 14-year-old boy in the UK also died of the new illness.
Several cases in Europe were detailed in a report published in the Lancet.
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Experts in the Lancet reported that abdominal pain, gastrointestinal symptoms and cardiac inflammation were common to the cases.
Dr Jane Newburger, the director of the Kawasaki program at Boston children’s hospital, confirmed In a press release through the American Heart Association that a small number of children developed serious inflammatory syndrome with COVID-19, often leading to hospitalisation.
Newburger said: “We want to reassure parents – this appears to be uncommon.
“While Kawasaki disease can damage the heart or blood vessels, the heart problems usually go away in five or six weeks, and most children fully recover.”
She continued: “Rarely, but sometimes, the coronary artery damage persists.
“Because of this, Kawasaki disease is the most common cause of acquired heart disease in children in developed countries.
“Prompt treatment is critical to prevent significant heart problems.”
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